Abstract:
Nitrogen doped carbon nanodots (NDCNDs) and nanosized cobalt tetra aminophenoxy
phthalocyanines (CoTAPhPcNPs) modified glassy carbon electrodes have been successfully used in
the simultaneous detection of aspirin (ASA), ibuprofen (IBU) and indomethacin (INDO). Scanning
electron microscopy (SEM), transmission electron microscopy (TEM), UV–Vis spectroscopy, Fourier
transform infrared spectroscopy (FTIR), cyclic voltammetry (CV) and electrochemical impedance
spectroscopy (EIS) were used to probe the nature of the synthesized nanomaterials.
Sequential deposition of the nanomaterials on the glassy carbon electrode yielded CoTAPhPcNPs-
NDCNDs-GCE with remarkable electrocatalytic performance. Electro-oxidation of the drugs at
the electrode surface was first order. This work demonstrates the synergic effect of the two nanomaterials
towards simultaneous electrocatalytic detection of the drugs. Superior detection limits
of ASA, IBU and INDO being 9.66 10
9 M, 4.19 10
9 M and 7.2 10
9 M, respectively, were
obtained using differential pulse voltammetry. The developed sensor could detect two of the three
(ibuprofen and indomethacin) simultaneously at significantly different potentials and exhibited
remarkable reproducibility after a regeneration step.
2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open
access article under the CC BY-NC-ND license
